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These information declare that striatal Nurr1 is an important mediator associated with formation of LID. Copyright © 2020 Sellnow et al.BACKGROUND AND OBJECTIVES At our establishment, we created an individualized discharge opioid prescribing and tapering protocol for combined replacement patients and applied similar protocol for neurosurgical back customers. We then tested the theory that this protocol will decrease the oral morphine milligram equivalent (MME) dose of opioid recommended po