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Majority of them (56.2%) were third-year students in the age range of 20-25 years. Drug and substance abuse among the undergraduate university students in Katsina State is common, and it cuts across both male and female students. Concerted efforts towards parental support and supervisions, social intervention programs, and campus-based prevention and supported programs against drug and substance abuse should be encouraged. Drug and substance abuse among the undergraduate university students in Katsina State is common, and it cuts across