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001). In multiple linear regression analysis, significant factors related to a higher dissection speed were the treatment method of ESTD (p 0.001) and larger specimen area (p 0.001). ESTD appears to be a safe and effective method to treat rectal LSTs. Compared with ESD, ESTD appears to achieve a higher dissection speed for rectal LSTs. ESTD appears to be a safe and effective method to treat rectal LSTs. Compared with ESD, ESTD appears to achieve a higher dissection speed for rectal LSTs. Natural history after endoscopic resect