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Key Findings The MS rats displayed obesity, high blood pressure, polydipsia, glucose and lipids metabolic process disorders, increased inflammatory cytokine, hepatic tissue morphological and functional harm, in addition to up-regulated expressions of ERS-related, autophagy-related proteins and p-mTOR, in addition to down-regulated expression of p-AMPKα. All aforementioned abnormalities in MS rats had been ameliorated in MS + CIHH rats. Importance In conclusion CIHH confers hepatic protection th