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We now have included proof from our very own laboratory scientific studies and from a comprehensive literary works search in databases PubMed, EMBASE, Scopus, as well as the electronic archives of abstracts provided in the yearly group meetings of the Pediatric educational Societies. In order to prevent prejudice in identification of current studies, key words had been short-listed before the actual search both from anecdotal experience and from PubMed's Medical Subject Heading (MeSH) thesaurus.