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metastatic trials), we did not observe any significant differences among the groups. No evidence of publication bias was observed. Compared with control, the addition of HER2 blockades may not increase the risk of FAEs among patients with breast cancer. Compared with control, the addition of HER2 blockades may not increase the risk of FAEs among patients with breast cancer. There are increasing rates of mastectomy and bi-lateral mastectomy in women diagnosed with ductal carcinoma in situ (DCIS). To help women avoid decisions that lead t