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We report a novel solvothermal route for the production of bassanite (CaSO4·0.5H2O) nanoparticles using amorphous Ca-ethoxide as a precursor. Bassanite nanorods, 120-200 nm in length, with the highest specific surface area reported so far (54 m2 g-1) and enhanced reactivity, are obtained at 78 °C and 1 atm. Such nanoparticles may find application in several fields, including biomaterials, drug delivery, and cultural heritage conservation.A novel electrochemical biosensor for detecting pathogenic bacteria was designed based on specific m