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Since the research of industrial CPS is still emerging, we also discuss existing approaches and novel solutions to overcome these sub-challenges. These insights will help researchers and industrial practitioners to develop and commercialize industrial CPS.Protein post-translational modifications (PTMs) play key roles in eukaryotes since they finely regulate numerous mechanisms used to diversify the protein functions and to modulate their signaling networks. Besides, these chemical modifications also take part in the viral hijacking of