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How Does Medication For ADHD Work? Many people find that taking medication can help ease their symptoms. However, finding the right drug and dosage is a process that takes patience, time, and communication with your GP or specialist. Treatments for ADHD are effective by altering the levels of certain chemical messengers within your brain. Stimulant drugs, such as methylphenidate can help reduce hyperactivity and impulsivity and help improve focus. Atomoxetine (Strattera) and Guanfacine (Tenex, Intun