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9% vs. 19.5%, = 0.007) and had higher HDL cholesterol (43.8 vs. 39.7 mg/dL, = 0.006). By comprehensively sequencing the coding regions of all MODY genes, we identified MODY in 2.8% of youth with clinically diagnosed type 2 diabetes; importantly, in 89% ( = 83) the specific diagnosis would have changed clinical management. No clinical criterion reliably separated the two groups. New tools are needed to find ideal criteria for selection of individuals for genetic testing. By comprehensively sequencing the coding regions of all MODY genes,
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