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Through a review of sternal morphology across Synapsida, we reconstruct the evolutionary history of this structure. Furthermore, we explore its role in the evolution of mammalian posture, gait, and ventilation through progressive regionalization of the postcranium as well as the posteriorization of musculature associated with mammalian breathing.The insertion of an endogenous retroviral long terminal repeat (LTR) sequence into the bovine apolipoprotein B (APO gene is causal to the inherited genetic defect cholesterol defi