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The use of cannabis to treat some symptoms of neurological diseases, including multiple sclerosis (MS), has increased worldwide. We aimed to assess the use of cannabis in patients with MS (PwMS) from Argentina, its reasons and patients' perceptions on the management of MS symptoms. Additionally, we assessed their association with socio-demographic and clinical aspects. A cross-sectional online survey that included 281 PwMS from Argentina was conducted. Screening instruments Demographics and clinical data, health-related QoL (MS Impact Sca