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Hypochloremia associated with congestive heart failure (CHF) in dogs is likely multifactorial. Loop diuretics cause 12 sodium [Na ]chloride [Cl ] loss, whereas water retention causes a 11 [Na ][Cl ] dilution. Mathematical [Cl ] correction separates these effects on [Cl ]. We hypothesized that corrected [Cl ] (c[Cl ]) would not differ from measured [Cl ] (m[Cl ]) in dogs with controlled CHF because of loop diuretics, and dogs with refractory CHF would have higher c[Cl ] than m[Cl ], indicating relative water excess. Seventy-one client-own