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Trans-fat intake in the second and third quartile increased the risk of CVD by OR 1.86 (95% CI 1.03-3.34) and 2.01 (95% CI 1.12-3.6, respectively. CONCLUSIONS while trans-fats may be significantly associated with the development of CVD in the first two quartiles, no association has been detected with other fat types.This article analyses, from 1989 until 2019, the development of the European Union legislation on food for special medical purposes, aimed at patients, and examines how from 1997 the competent scientific bodies of the Euro