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Population aging is a global challenge and the degree of population aging is continuing to deepen in China. Under the active aging policy framework by WHO, great importance has been attached to aging women and participation is emphasized for the well-being of the elderly. This study aimed to investigate the relation between social participation and self-rated health status of aging women in China and whether caring for grandchildren mediated such an association. Adopting data from the 2018 China Health and Retirement Longitudinal Study (C