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Cases from tracts with 20% poverty changed residential tracts more often (42%) than cases from tracts with 20%) had a 30% higher risk of regional-stage colon cancer death than cases in the lowest category ( less then 5%) (95% confidence interval [CI] 1.04-1.63). Conclusion Residential changes after regional-stage colon cancer diagnosis may be associated with a higher risk of colon cancer death among cases in high-poverty areas. This has important implications for post-diagnostic access to care for treatment and follow-up surveillance.