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05, -18%). In response to overfeeding, CT participants increased their intramuscular triglycerides content in type I (p less then 0.01, +10%) and type IIA (p less then 0.01, +9%) muscle fibers. CT individuals seem to present an unusual muscle phenotype and different adaptations to overfeeding compared to normal-weight participants, suggesting a specific energy metabolism and muscle adaptations. NCT02004821 Novelty ●Low intramuscular triglycerides and glycogen content in skeletal muscle of constitutionally thin individuals ●Low oxidative