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54-0.90; p less then 0.01, I 2 = 40%), thrombocytopenia (RR 0.66; 95% CI 0.46-0.96; p less then 0.05, I 2 = 32%), and nausea and vomiting (RR 0.50; 95% CI 0.32-0.80; p less then 0.01, I 2 = 85%). Hepatic dysfunction (RR 0.63; 95% CI 0.33-1.20; p = 0.16, I 2 = 0%), neurotoxicity (RR 0.64; 95% CI 0.26-1.55; p = 0.32, I 2 = 0%), and anemia (RR 0.65; 95% CI 0.40-1.04; p = 0.07, I 2 = 0%) were similar between the two groups. Evidence from the meta-analysis suggested that compared with paclitaxel-based chemotherapy alone, the combination of T