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Three instances with difference company in COL4A genes and one case without variation company had sight issue. Additionally, one situation with difference provider in COL4A gene had reading loss. All instances with variation carrier in COL4A genes exclude one had at least one cardiac problems. Additionally, all situations with difference carrier in COL4A genes had possible reasons for hereditary thrombophilia risk. As well as developing danger of modern kidney failure, sensorineural hearing loss
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