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Multivariate Cox regression analyses revealed that overestimated renal function was a significant and independent factor predictive of poor prognosis in the entire cohort (HR 2.050; 95% CI 1.041-4.037; p=0.038) and in subgroups classified by Child-Pugh class A (HR 2.131; 95% CI 1.019-4.458; p=0.044), Model for End-Stage Liver Disease score ≤9 (HR 2.303; 95% CI 1.038-5.109; p=0.04), and presence of HCC (HR 2.290; 95% CI 1.128-4.651; p=0.022). Overestimated renal function is a significant and independent prognostic factor in patients with