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Thus, our data reveal neuronal Hv1 as a novel target in analgesia strategy and managing opioids-related side effects.Chronic Pb exposure associated systemic illness are partly posited to involve calcium homeostasis. Present systematic review aims to comprehensively evaluate the association between chronic lead exposure and markers of calcium homeostasis. Observational studies documenting the changes in calcium homeostasis markers (i.e. serum calcium, parathyroid hormone, vitamin D calcitonin) between occupationally Pb exposed grou