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y across a range of serious mental health problems and provide choice about available care. ISRCTN34966555. Date of first registration 12 June 2014. ISRCTN34966555. Date of first registration 12 June 2014. Bisphosphonates (BPs) are the most commonly used drugs in osteoporosis. This review focuses on the criteria for identifying patients who should be treated with BPs and also the rational for the duration of treatment. BPs remain the mainstay for the treatment of osteoporosis. For their low cost, the treatment threshold is related exclusively to the ratio b