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Stimulant Vs Non Stimulant ADHD Medication The most common prescription medication prescribed by healthcare professionals to treat ADHD is stimulants. These drugs target specific chemicals in the brain, like norepinephrine and dopamine, to reduce symptoms like the inability to focus and impulsivity. Nonstimulant medications are an alternative to treatment for those who aren't able to respond to stimulants. They also have less adverse effects. They target different neurotransmitters, or receptors. Th