Mesothelioma Settlements The majority of mesothelioma lawsuits settle with settlements, not an appeal to a jury. In negotiations, defendants take into account many factors, including treatment costs as well as lost income. A settlement from a lawsuit involving mesothelioma may help the victim and their families. Lawsuits also hold companies accountable for asbestos exposure. The mesothelioma settlement average is approximately $1 million. Compensation for Suffering and Pain Compensation is available to victims of mesothelioma or their family