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A group of thiosemicarbazones were prepared and their structures were confirmed by spectroscopic methods such as IR and H-NMR, mass spectrometry and also analytical method like elemental analysis. The synthesized semicarbazones were then assessed for their inhibitory activity against bacterial strains including species, Enterobacter faecalis, methicillin-resistant , and fungi such as and . The schiff bases of isatin ( - ) were prepared by a condensation reaction between thiosemicarbazide and substituted N-aryl isatins leading to the des