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The planned second part of this study will discuss the non-thermal effects and present the most important epidemiological studies. The Comparison of Methylphenidate and Psychotherapy in adult ADHD Study (COMPAS) was a prospective, randomized multicenter clinical trial, comparing methylphenidate (MPH) with placebo (PLAC) in combination with cognitive behavioral group psychotherapy (GPT) or individual clinical management (CM) over the period of 1 year. Here, we report results on treatment safety. MPH and PLAC were flexibly dosed. Among 433 randomized patients
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