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Best Medication For ADHD Medication is a crucial part of the majority of treatment plans for ADHD. Finding the right dosage and medication may take a while. Be patient and open to communicating with your doctor. Stimulants work by increasing levels of chemicals in the brain that control behavior. They are available in short-acting as well as long-acting versions. Short-acting medicines peak after a few hours and should be taken three times per day. Long-acting medication lasts 8-12 hours, and is