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In the present research, we investigate the direct effectation of pH in synergy with RGD peptide based targeting in the healing efficacy of chitosan nanoparticles (RGD-CHNPs) in breast cancer. Moreover, the very first time we performed a comprehensive research showing the anti-tumor, anti-migratory and anti-angiogenic aftereffect of raloxifene (Rlx) loaded CHNPs in breast cancer. We ready steady formulations of raloxifene encapsulated CHNPs and RGD-CHNPs by the nontoxic ionic gelation method. pH d