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For 2, a single resonance frequency is obtained, while for 6 two transitions are seen, with the lower-energy transition being less intense. The results demonstrate how subtle changes in substitution exert large effects in optical properties.Thrombospondins are encoded in vertebrates by a family of 5 THBS genes. THBS1 is infrequently mutated in most cancers, but its expression is positively regulated by several tumor suppressor genes and negatively regulated by activated oncogenes and promoter hypermethylation. Consequently, thrombospondin-
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