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Lead neurotoxicity is associated with numerous alterations including behavioral and neurochemical disruptions. This study evaluates the possible neurochemical disruption in the subcommissural organ (SCO) after acute (three days) and subchronic (six weeks) Pb-exposure inMeriones shawi, and the possible effect of the third active compound, curcumin-III, in mitigating the neurological alterations caused by lead exposure. Using immunohistochemical stainings, we evaluated the Reissner's fiber (RF) secretion utilizing RF-antibody in the SCO.