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When you look at the phantom study, we obtained 100 and 94.7% monitoring accuracy in 3 cm and 2 cm spherical masses, correspondingly. This needed 32.5 ms/frame (30.8 fps) real time handling. CONCLUSIONS We proved the possibility feasibility of a real-time markerless tumour monitoring framework for stereotactic lung radiotherapy based on patient-specific DL with personalised information generation with electronic phantom and epoxy phantom studies. ADVANCES IN KNOWLEDGE utilizing DL with personalised informatio