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Nevertheless, adverse effects of PQ regarding the neuroimmune interactions have seldom been investigated. Female adult C57/BL6 mice had been divided in to 3 teams and treated with PQ (intraperitoneal injection, 1 mg/kg or 5 mg/kg) or the automobile (an equivalent level of 0.9% saline) every two days, at time 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, for an overall total of 14 doses. We evaluated blood-brain barrier (BB stability and PQ concentrations throug