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To determine patient-specific risk factors and clinical outcomes associated with contaminated blood cultures. A single-center, retrospective case-control risk factor and clinical outcome analysis performed on inpatients with blood cultures collected in the emergency department, 2014-2018. Patients with contaminated blood cultures (cases) were compared to patients with negative blood cultures (controls). A 509-bed tertiary-care university hospital. Risk factors independently associated with blood-culture contamination were determined us