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Colorectal cancer mortality trends were downward for the last decades with favorable predictions for 2022 in both sexes. In the countries considered, predicted downward trends started later and were less marked than those in the European Union and the USA. Despite overall favorable predictions, colorectal cancer remains one of the major causes of cancer mortality. In the countries considered, predicted downward trends started later and were less marked than those in the European Union and the USA. Despite overall favorable predictions,