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Despite the positive achievements attained, the treatment of male urethral strictures and hypospadiases still remains a challenge, particularly, in cases of severe urethral defects. Complication rate and need for additional interventions in such cases are the highest. Also, shortage of autologous tissue for graft harvesting and significant morbidity on the place of harvesting present a problem and often lead to staged treatment. Tissue engineering provides a promising alternative to the current sources of grafts for urethroplasty. Since