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The findings summarized in this review will contribute to guide interventions in clinical practice or in future clinical studies. Several studies explored the effects of caffeine on isometric handgrip strength, but their findings varied. Therefore, the aim of this review was to perform a meta-analysis of studies exploring the effects of caffeine on isometric handgrip strength. Search for studies was performed through five databases (Academic Search Elite, Cochrane Library, PubMed/MEDLINE, SPORTDiscus, and Scopus) with additional second