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ng the MCID of SF-36 scores among ICU patients and standardizing the PICS definition are required. Trial registration UMIN000034072. Among the survivors who received mechanical ventilation, 64% had PICS at 6 months; co-occurrence of PICS impairments occurred in 20%. PICS was associated with population with only mandatory education. Future studies elucidating the MCID of SF-36 scores among ICU patients and standardizing the PICS definition are required. Trial registration UMIN000034072. Therapeutic antibodies targeting programmed cell deat