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Among various kinds of 2nd messengers, cyclic nucleotides cAMP and cyclic di-GMP (c-di-GMP) play pivotal functions in microbial ecological responses. However, exactly how these signaling systems tend to be interconnected for a concerted regulation of cellular physiology remains evasive. In a thermophilic cyanobacterium Thermosynechococcus vulcanus stress RKN, incident light color is sensed by cyanobacteriochrome photoreceptors to transduce the light information into th