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Further, psycho-physiological interactions showed that functional connectivity between left hippocampal subfields and caudate decreased when temporal expectations were not met. Our results indicate that the hippocampus and striatum cooperate to process implicit temporal expectation from mnemonic associations. Our findings provide further support for a hippocampal-striatal network in temporal associative processing. © 2020 The Authors. Hippocampus published by Wiley Periodicals, Inc.The humanized mouse (HM) has emerged as a valuable animal