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Background Photodynamic therapy (PDT) is an effective and safe treatment modality for acne vulgaris, and a variety of light sources have been investigated. Sunlight has been used as a PDT light source in limited acne studies over the past years. However, to date, a comparative study of conventional PDT (C-PDT) and daylight PDT (DL-PDT) on acne is still lacking. Objectives This study aims to assess the efficacy and safety of DL-PDT vs. C-PDT in the treatment of acne vulgaris. Methods Eighty patients with facial moderate-to-severe acne vulgar