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Results from Rio de Janeiro were available from 2013 to 2016 with incidence in first-time donors of 35·9/10 py and repeat donors from 2011 to 2016 of 29·2/10 py. Incidence varied by other donor demographics. When incidence was considered in 2-year intervals, no significant trend was evident. Overall residual risk of TT-HIV was 5·46 and 7·41 per million units of pRBC and FFP transfused, respectively. HIV incidence in both first-time and repeat donors varied by region in Brazil. Clear secular trends were not evident. HIV incidence in both f