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The same was true for patients with -7 across morphological subtypes. We demonstrate that HSCT outcome is independent of GATA2 germline mutations in pediatric MDS suggesting the application of standard MDS algorithms and protocols. Our data support considering HSCT early in the course of GATA2 deficiency in young individuals.Since the introduction of nickel-titanium endodontic instruments, there have been a myriad of developments which can be confusing and sometimes contradictory. This article seeks to review and articulate these advanc