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Secondly, the paper addresses applicability domain issues, in particular the problem of deciding whether or not the kDPRA is applicable for a given chemical.Underlying infection, estimated blood loss 500 ml and operative delivery are independent risk factors for breakdown of perineal laceration repair after vaginal birth. First, we investigated whether the exposure to different visual feedback conditions may modulate pain perception by means of visual induced analgesia in patients with chronic migraine. Second, to comprehend the way