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rovides the atomistic insights into DHA-induced regulatory mechanism of monomeric α-synuclein, having implications in protein structure and its physiological/pathological functions.Interaction of the conjugated structure in melanin contributed to photothermal conversion. Inspired by this, here, we first demonstrated that lignin nanoparticles (L-NPs) can carry out photothermal conversion, which was attributed to π-π stacking of lignin molecules. Lignin can be readily converted into L-NPs, using the self-assembly method at room temperatu