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190 (95% CI 0.133, 0.247), 0.184 (95% CI 0.117, 0.252), and 0.194 (95% CI 0.086, 0.301). Mediation analysis showed that visceral fat accumulation contributed to 51.37%, 53.85%, and 26.51% of obesity-induced hepatic steatosis in the total, female, and male subjects, respectively. Visceral fat accumulation partially mediates obesity-induced hepatic steatosis in overweight and obese individuals, especially in women. More focus on visceral fat reduction is needed in obese individuals. Visceral fat accumulation partially mediates obesity-in