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eatment efficacy of the proposed intervention. Clinicaltrials.gov, identifier NCT04068922 . Registered 28 August 2019. Clinicaltrials.gov, identifier NCT04068922 . Registered 28 August 2019. To report a clinical case of a patient affected with choroideremia (CHM) who underwent macular surgery for a macular hole (MH) with Lamellar Hole-associated Epiretinal Proliferation (LHEP). We have described a 48-year-old male patient affected with CHM who developed MH with LHEP over a 7-year follow-up. The patient was referred to the Regional Center