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Switching of the Ce3+/Ce4+ oxidation states in cerium oxide nanoparticles (CNPs) provides various superior nanozyme activities. However, nanozymes lack a switch to reversibly regulate the multi-nanozyme capacity depending on physiological/pathological environments, e.g. link2 different pH and H2O2 levels. Furthermore, highly concentrated Ce3+ ions with abundant oxygen vacancies (Vo) in CNPs have the potential to enhance their catalytic activities, but the phosphate anions (P) adsorbed on Ce3+ ions block their several catalytic activitie