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Among patients with atypical atrial flutter, likelihood of recurrent atrial flutter was similar between the DOF (43 of 108 [40%]) and AMIO (211 of 555 [38%]; p=0.69) groups. When properly initiated and monitored, DOF has efficacy comparable to that of amiodarone forrhythmcontrol in patients with AF. When properly initiated and monitored, DOF has efficacy comparable to that of amiodarone for rhythm control in patients with AF. This study sought to evaluate direct oral anticoagulant (DOAC) outcomes (vs. warfarin) in patients with atrial fi