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05). In patients with DLCO less then LLN, severe respiratory mechanical constraints, indicated by end-inspiratory lung volume of approximately 90% of total lung capacity, occurred at a lower WR than the other two groups (p less then 0.05). The dyspnea/IND relationship was similar across groups; therefore, the increased dyspnea at a standardized WR in the low DLCO less then LLN group reflected the higher corresponding IND. Higher dyspnea ratings in patients with mild COPD and DLCO less then LLN were associated with higher IND and V̇E/V