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The addition of β-Lg and β-CN showed better protective effects on antioxidant activity. The bioaccessibility of tea catechins mixed with β-Lg is significantly higher than that of tea catechins mixed with β-CN in the gastrointestinal digestion stage, except for the mixture of EC and β-CN. The increase in catechin bioaccessibility and antioxidant activity was positively correlated to the binding affinity of catechins-proteins.During storage, beer staling coincides with a gradual increase in the concentrations of aldehydes resulting in the